Sources of Variability in pre-Bötzinger Complex Rhythmic Patterns Generated by a Transverse Slice
نویسندگان
چکیده
6 Simplex parameter fits of how computational time scales with network size 47 v
منابع مشابه
Developmental changes in the hypoxic response of the hypoglossus respiratory motor output in vitro.
The transverse brain stem slice of mice containing the pre-Bötzinger complex (PBC), a region essential for respiratory rhythm generation in vitro, was used to study developmental changes of the response of the in vitro respiratory network to severe hypoxia (anoxia). This preparation generates, at different postnatal stages [postnatal day (P)0-22], spontaneous rhythmic activity in hypoglossal (X...
متن کاملIsolation of the kernel for respiratory rhythm generation in a novel preparation: the pre-Bötzinger complex "island".
The pre-Bötzinger complex (pre-BötC), a bilaterally distributed network of rhythmogenic neurons within the ventrolateral medulla, has been proposed to be the critical locus for respiratory rhythm generation in mammals. To date, thin transverse medullary slice preparations that capture the pre-BötC have served as the optimal experimental model to study the region's inherent cellular and network ...
متن کاملPoint:counterpoint Comments
To the Editor: Eupnea is characterized by several systems criteria important for breathing, including specific shapes of discharge patterns in phrenic and other nerves and temporal relationships between them (1, 3, 5, 6). Identification of eupnea in slice based on firing patterns of single neurons or mass activity in the pre-Bötzinger complex (2, 4) does not meet these criteria and makes no sen...
متن کاملOpioid-Induced Quantal Slowing Reveals Dual Networks for Respiratory Rhythm Generation
Current consensus holds that a single medullary network generates respiratory rhythm in mammals. Pre-Bötzinger Complex inspiratory (I) neurons, isolated in transverse slices, and preinspiratory (pre-I) neurons, found only in more intact en bloc preparations and in vivo, are each proposed as necessary for rhythm generation. Opioids slow I, but not pre-I, neuronal burst periods. In slices, opioid...
متن کاملSodium and calcium mechanisms of rhythmic bursting in excitatory neural networks of the preBtzinger complex: a computational modelling study
The neural mechanisms generating rhythmic bursting activity in the mammalian brainstem, particularly in the pre-Bötzinger complex (pre-BötC), which is involved in respiratory rhythm generation, and in the spinal cord (e.g. locomotor rhythmic activity) that persist after blockade of synaptic inhibition remain poorly understood. Experimental studies in rodent medullary slices containing the preBö...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2004